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Org Lett. 2006 Mar 30;8(7):1383-6.

Effective acceleration of atom transfer carbonylation of alkyl iodides by metal complexes. Application to the synthesis of the hinokinin precursor and dihydrocapsaicin.

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  • 1Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.


[reaction: see text] Atom transfer carbonylation (ATC) of alkyl iodides leading to carboxylic acid esters is effectively accelerated by Pd(PPh(3))(4) and Mn(2)(CO)(10) under photoirradiation conditions. In the presence of amines, Pd(0) complexes affected double carbonylations leading to alpha-keto amides, whereas Mn(2)(CO)(10) accelerated only a single carbonylation reaction leading to the corresponding amides. The Pd(0)-accelerated ATC system was successfully applied to the synthesis of hinokinin and dihydrocapsaicin.

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