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    Science. 2006 Mar 24;311(5768):1774-5.

    Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

    Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH.

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    Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA. achong@uchicago.edu

    Abstract

    Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.

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    PMID:
    16556844
    [PubMed - indexed for MEDLINE]

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