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Science. 2006 Apr 21;312(5772):452-4. Epub 2006 Mar 23.

RNA interference directs innate immunity against viruses in adult Drosophila.

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  • 1Graduate Program for Microbiology, University of California, Riverside, CA 92521, USA.

Abstract

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

PMID:
16556799
[PubMed - indexed for MEDLINE]
PMCID:
PMC1509097
Free PMC Article

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