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1: Nature. 2006 Mar 23;440(7083):470-6.Click here to read Links

KATP channels as molecular sensors of cellular metabolism.

Nichols CG.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. cnichols@cellbio.wustl.edu

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K(ATP)) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.

PMID: 16554807 [PubMed - indexed for MEDLINE]

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