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    Neurology. 2006 Jun 27;66(12):1917-9. Epub 2006 Mar 22.

    Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.

    Source

    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany. schuerks@hotmail.com

    Abstract

    The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).

    PMID:
    16554494
    [PubMed - indexed for MEDLINE]

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