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Alcohol Alcohol. 2006 May-Jun;41(3):231-5. Epub 2006 Mar 22.

Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats.

Author information

  • 1The Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Abstract

AIMS:

To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats.

METHODS:

Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis.

RESULTS:

Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde.

CONCLUSIONS:

Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.

PMID:
16554376
[PubMed - indexed for MEDLINE]
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