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A microbial world within us.
Wageningen University and Wageningen Centre for Food Sciences, Laboratory of Microbiology, the Netherlands.
The microbial world within us includes a vast array of gastrointestinal (GI) tract communities that play an important role in health and disease. Significant progress has been made in recent years in describing the intestinal microbial composition based on the application of 16S ribosomal RNA (rRNA)-based approaches. These were not only instrumental in providing a phylogenetic framework of the more than 1000 different intestinal species but also illustrated the temporal and spatial diversity of the microbial GI tract composition that is host-specific and affected by the genotype. However, our knowledge of the molecular and cellular bases of host-microbe interactions in the GI tract is still very limited. Here an overview is presented of the most recent developments and applications of novel culture-independent approaches that promise to unravel the mechanisms of GI tract functionality and subsequent possibilities to exploit specifically these mechanisms in order to improve gut health.
PMID: 16553872 [PubMed - indexed for MEDLINE]
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Cited by 16 PubMed Central articles
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Lactobacillus fermentum ME-3 - an antimicrobial and antioxidative probiotic.
Mikelsaar M, Zilmer M.
Microb Ecol Health Dis. 2009 Mar 16; . Epub 2009 Mar 16.
[Microb Ecol Health Dis. 2009]
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Application of sequence-dependent electrophoresis fingerprinting in exploring biodiversity and population dynamics of human intestinal microbiota: what can be revealed?
Huys G, Vanhoutte T, Vandamme P.
Interdiscip Perspect Infect Dis. 2008; 2008:597603. Epub 2008 Dec 14.
[Interdiscip Perspect Infect Dis. 2008]
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Surface displaced alfa-enolase of Lactobacillus plantarum is a fibronectin binding protein.
Castaldo C, Vastano V, Siciliano RA, Candela M, Vici M, Muscariello L, Marasco R, Sacco M.
Microb Cell Fact. 2009 Feb 16; 8:14. Epub 2009 Feb 16.
[Microb Cell Fact. 2009]
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