Infect Immun. 2006 Apr;74(4):2446-8.

Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.

Wells J, Haidaris CG, Wright TW, Gigliotti F.

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Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 690, 601 Elmwood Ave., Rochester, NY 14642, USA.

Abstract

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thioredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii.

PMID:: 16552076; [PubMed - indexed for MEDLINE]
PMCID: PMC1418926

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