Emerg Med J. 2006 Apr;23(4):246-50.

Treatment of poisoning induced cardiac impairment using cardiopulmonary bypass: a review.

Purkayastha S, Bhangoo P, Athanasiou T, Casula R, Glenville B, Darzi AW, Henry JA.

Source

Department of Biosurgery and Surgical Technology, Imperial College, St Mary's Hospital, London, UK.

Abstract

Severe poisoning can cause potentially fatal cardiac depression. Cardiopulmonary bypass (CPB) can support the depressed myocardium, but there are no clear indications or guidelines available on its use in severe poisoning. A review was conducted of relevant papers in the available literature (seven single case reports of both deliberate and accidental ingestion of cardiotoxic drugs and two animal studies). Although CPB is rarely used in the management of poisoning, it may have potential benefits for haemodynamic instability not responding to conventional measures. At present there is insufficient evidence concerning the use of CPB as a treatment for severe cardiac impairment due to poisoning (grade C). This review suggests that in patients with severe and potentially prolonged reversible cardiotoxicity there is potential for full survival with CPB, provided that the patient has not already sustained hypoxic cerebral damage due to resistant hypotension prior to its use.

PMID:: 16549566; [PubMed - indexed for MEDLINE]
PMCID:: PMC2579492

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Anti-Arrhythmia Agents

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity. [Crit Care. 2007]
Review Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity.
Baud FJ, Megarbane B, Deye N, Leprince P. Crit Care. 2007; 11(2):207.
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. [Clin Toxicol (Phila). 2007]
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management.
Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, Wax PM, Manoguerra AS, Scharman EJ, Olson KR, et al. Clin Toxicol (Phila). 2007; 45(3):203-33.
Extracorporeal circulatory support in near-fatal flecainide overdose. [Anaesth Intensive Care. 1999]
Extracorporeal circulatory support in near-fatal flecainide overdose.
Corkeron MA, van Heerden PV, Newman SM, Dusci L. Anaesth Intensive Care. 1999 Aug; 27(4):405-8.
Final Report on Carcinogens Background Document for Formaldehyde. [Rep Carcinog Backgr Doc. 2010]
Final Report on Carcinogens Background Document for Formaldehyde.
National Toxicology Program. Rep Carcinog Backgr Doc. 2010 Jan; (10-5981):i-512.
Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass. [Ann Emerg Med. 1994]
Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass.
Larkin GL, Graeber GM, Hollingsed MJ. Ann Emerg Med. 1994 Mar; 23(3):480-6.

See reviews... See all...

Cited by 4 PubMed Central articles

Toxic bradycardias in the critically ill poisoned patient. [Emerg Med Int. 2012]
Toxic bradycardias in the critically ill poisoned patient.
Givens ML. Emerg Med Int. 2012; 2012:852051. Epub 2012 Apr 1.
Extracorporeal life support for severe drug-induced cardiotoxicity: a promising therapeutic choice. [Crit Care. 2009]
Extracorporeal life support for severe drug-induced cardiotoxicity: a promising therapeutic choice.
Ashrafian H, Athanasiou T. Crit Care. 2009; 13(5):187. Epub 2009 Sep 24.
Extracorporeal life support in severe drug intoxication: a retrospective cohort study of seventeen cases. [Crit Care. 2009]
Extracorporeal life support in severe drug intoxication: a retrospective cohort study of seventeen cases.
Daubin C, Lehoux P, Ivascau C, Tasle M, Bousta M, Lepage O, Quentin C, Massetti M, Charbonneau P. Crit Care. 2009; 13(4):R138. Epub 2009 Aug 25.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Treatment of poisoning induced cardiac impairment using cardiopulmonary bypass: ...
Treatment of poisoning induced cardiac impairment using cardiopulmonary bypass: a review.
Emerg Med J. 2006 Apr ;23(4):246-50.

PubMed
Critique of the considerations for establishing the tolerable upper intake level...
Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards.
J Nutr. 2006 Apr ;136(4):1117-22.

PubMed
Long-term administration of green tea catechins improves spatial cognition learn...
Long-term administration of green tea catechins improves spatial cognition learning ability in rats.
J Nutr. 2006 Apr ;136(4):1043-7.

PubMed
The maximal amount of dietary alpha-tocopherol intake in U.S. adults (NHANES 200...
The maximal amount of dietary alpha-tocopherol intake in U.S. adults (NHANES 2001-2002).
J Nutr. 2006 Apr ;136(4):1021-6.

PubMed
Consumption of Bing sweet cherries lowers circulating concentrations of inflamma...
Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women.
J Nutr. 2006 Apr ;136(4):981-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: