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    Biochem Biophys Res Commun. 1991 Sep 16;179(2):852-8.

    Effect of okadaic acid on hormone- and mastoparan-stimulated phosphoinositide turnover in isolated rat hepatocytes.

    García-Sáinz JA, Macías-Silva M, Romero-Avila MT.

    Source

    Instituto de Fisiología Celular, UNAM, México D. F.

    Abstract

    Okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A which seems to be useful for identifying biological processes that are controlled by reversible phosphorylation of proteins. We report here that okadaic acid inhibits in isolated hepatocytes the stimulations of phosphoinositide turnover induced by epinephrine, angiotensin II and vasopressin. Mastoparan, a peptide toxin from wasp venom that mimics receptors by activating G-proteins, also stimulates the accumulation of inositol phosphates in hepatocytes. Interestingly, this action of mastoparan was also inhibited by okadaic acid. Our data indicate that okadaic acid inhibits the phosphoinositide turnover signal transduction system in hepatocytes at a level distal to the receptors.

    PMID:
    1654901
    [PubMed - indexed for MEDLINE]

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