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Opt Lett. 2006 Mar 15;31(6):775-7.

Diffraction phase microscopy for quantifying cell structure and dynamics.

Author information

  • 1George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. gpopescu@mit.edu

Abstract

We have developed diffraction phase microscopy as a new technique for quantitative phase imaging of biological structures. The method combines the principles of common path interferometry and single-shot phase imaging and is characterized by subnanometer path-length stability and millisecond-scale acquisition time. The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells.

PMID:
16544620
[PubMed - indexed for MEDLINE]
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