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Science. 2006 Mar 17;311(5767):1617-21.

Parietal-eye phototransduction components and their potential evolutionary implications.

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  • 1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. chih-ying.su@yale.edu

Abstract

The parietal-eye photoreceptor is unique because it has two antagonistic light signaling pathways in the same cell-a hyperpolarizing pathway maximally sensitive to blue light and a depolarizing pathway maximally sensitive to green light. Here, we report the molecular components of these two pathways. We found two opsins in the same cell: the blue-sensitive pinopsin and a previously unidentified green-sensitive opsin, which we name parietopsin. Signaling components included gustducin-alpha and Galphao, but not rod or cone transducin-alpha. Single-cell recordings demonstrated that Go mediates the depolarizing response. Gustducin-alpha resembles transducin-alpha functionally and likely mediates the hyperpolarizing response. The parietopsin-Go signaling pair provides clues about how rod and cone phototransduction might have evolved.

PMID:
16543463
[PubMed - indexed for MEDLINE]
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