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    Science. 2006 Apr 28;312(5773):592-6. Epub 2006 Mar 16.

    SV2 is the protein receptor for botulinum neurotoxin A.

    Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER.

    Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, WI 53706, USA.

    Comment in:

    How the widely used botulinum neurotoxin A (BoNT/A) recognizes and enters neurons is poorly understood. We found that BoNT/A enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C). Fragments of SV2 that harbor the toxin interaction domain inhibited BoNT/A from binding to neurons. BoNT/A binding to SV2A and SV2B knockout hippocampal neurons was abolished and was restored by expressing SV2A, SV2B, or SV2C. Reduction of SV2 expression in PC12 and Neuro-2a cells also inhibited entry of BoNT/A, which could be restored by expressing SV2 isoforms. Finally, mice that lacked an SV2 isoform (SV2B) displayed reduced sensitivity to BoNT/A. Thus, SV2 acts as the protein receptor for BoNT/A.

    PMID: 16543415 [PubMed - indexed for MEDLINE]

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