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    Psychiatr Genet. 2006 Apr;16(2):73-6.

    A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia.

    Philibert RA.

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    Department of Psychiatry, Neuroscience Program, The University of Iowa, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu

    Abstract

    Uncommon polymorphisms, particularly balanced uncommon polymorphisms, present a significant challenge to our understanding of their role in behavior. We have recently demonstrated that an uncommon candidate gene polymorphism for schizophrenia, known as HOPA12bp, is the defining polymorphism for a large X-chromosome haplotype in population disequilibrium and that it is associated with a positive syndrome of psychosis. Not all studies, however, have shown this effect. In this report, we reviewed prior studies and conducted meta-analysis of studies using probands of northern European extraction. We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association.

    PMID:
    16538184
    [PubMed - indexed for MEDLINE]

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