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Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter.
Department of Anesthesiology, University of Wisconsin, Madison 53705.
A human clone corresponding to the gene encoding the alpha 1 subunit of the cardiac dihydropyridine-sensitive calcium channel (CCHL1A1) has been isolated and partially sequenced. Oligonucleotides based on the human sequence were constructed and used in the polymerase chain reaction to amplify specifically this human gene in human-rodent somatic cell hybrids. Using somatic cell hybrids that contained defined regions of human chromosome 12, the human alpha 1 subunit of the cardiac dihydropyridine-sensitive calcium channel has been assigned to the short arm of chromosome 12 in the interval 12p12-pter.
PMID: 1653763 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
Burgess DL, Davis CF, Gefrides LA, Noebels JL.
Genome Res. 1999 Dec; 9(12):1204-13.
[Genome Res. 1999]
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Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.
Schultz D, Mikala G, Yatani A, Engle DB, Iles DE, Segers B, Sinke RJ, Weghuis DO, Klöckner U, Wakamori M.
Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):6228-32.
[Proc Natl Acad Sci U S A. 1993]
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ReviewThe genetics of malignant hyperthermia.
Ball SP, Johnson KJ.
J Med Genet. 1993 Feb; 30(2):89-93.
[J Med Genet. 1993]
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