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Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4362-5. Epub 2006 Mar 14.

Suppressing Brownian motion of individual biomolecules in solution.

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  • 1Department of Physics, Stanford University, 381 Via Pueblo Mall, Stanford, CA 94305, USA.


Single biomolecules in free solution have long been of interest for detailed study by optical methods, but Brownian motion prevents the observation of one single molecule for extended periods. We have used an anti-Brownian electrokinetic (ABEL) trap to trap individual protein molecules in free solution, under ambient conditions, without requiring any attachment to beads or surfaces. We also demonstrate trapping and manipulation of single virus particles, lipid vesicles, and fluorescent semiconductor nanocrystals.

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