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Zhonghua Zhong Liu Za Zhi. 1991 Jan;13(1):9-12.

[Reversing effect of retinoic acid on some phenotypes of human hepatocarcinoma cell line].

[Article in Chinese]

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  • 1Shanghai Medical College.

Abstract

Reversing effect of retinoic acid (RA) on some phenotypes of human hepatocarcinoma cell line was studied. It was found that the growth of SMMC-7721 human hepatocarcinoma cell line was markedly inhibited when cultured in 10 mumol/L RA. Morphology of cells treated with RA reversed to normal when observed under light and electron microscopes and by image analysis. The 3H-TdR incorporation declined. By flow cytometry, it was observed that cells in G0/G1 phase increased from 49.6% to 59.1%, whereas cells in S or G2 + M phase decreased from 50.4% to 40.9% after 3-day RA treatment. The major distribution of chromosomes changed from 48-56 to 44-50 with an increase in diploid (from 4% to 15%). The results indicate that RA could reverse some phenotypes of human hepatocarcinoma cell line.

PMID:
1653693
[PubMed - indexed for MEDLINE]
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