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Nat Rev Genet. 2006 May;7(5):395-401.

Inherited epigenetic variation--revisiting soft inheritance.

Author information

  • Department of Biology, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA. richards@biology2.wustl.edu

Abstract

Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?

PMID:
16534512
[PubMed - indexed for MEDLINE]
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