Inherited epigenetic variation--revisiting soft in...[Nat Rev Genet. 2006]

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1: Nat Rev Genet. 2006 May;7(5):395-401. Links

Inherited epigenetic variation--revisiting soft inheritance.

Richards EJ.

Department of Biology, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA. richards@biology2.wustl.edu

Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?

PMID: 16534512 [PubMed - indexed for MEDLINE]

Epigenetic variation and inheritance in mammals. [Curr Opin Genet Dev. 2006]
Timescales of genetic and epigenetic inheritance. [Cell. 2007]
The inheritance of acquired epigenetic variations. [J Theor Biol. 1989]
Epigenetic inheritance and the intergenerational transfer of experience. [Psychol Bull. 2005]
Epigenetics and phenotypic variation in mammals. [Mamm Genome. 2006]
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Inherited epigenetic variation--revisiting soft inheritance.

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