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J Exp Med. 2006 Mar 20;203(3):505-11. Epub 2006 Mar 13.

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

Tadokoro CE, Shakhar G, Shen S, Ding Y, Lino AC, Maraver A, Lafaille JJ, Dustin ML.

Source

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

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J Exp Med. 2006 Mar 20;203(3):489-92.

PMID:: 16533880; [PubMed - indexed for MEDLINE]
PMCID:: PMC2118249

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