Format

Send to:

Choose Destination
See comment in PubMed Commons below
Semin Perinatol. 2005 Dec;29(6):367-75.

Down syndrome screening in the first and second trimesters: what do the data show?

Author information

  • 1Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

Recent advances in Down syndrome screening are providing women with additional options in how they are assessed for this condition. First trimester screening tests are at least as accurate as traditional second trimester testing and provide results earlier in a woman's pregnancy. Combining first and second trimester results increases the sensitivity and specificity of screening and reduce the number of women requiring invasive testing. This review summarizes and critiques the available data on Down syndrome screening and compares different testing algorithms. Meta-analyses of first trimester screening techniques are presented. Nuchal lucency measurements and other first trimester ultrasound markers, first trimester serum markers, and methods for combining these screens are addressed.

PMID:
16533649
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk