Curr Opin Cell Biol. 1991 Apr;3(2):213-7.

Cyclic AMP second messenger systems.

Source

Department of Pharmacology, University of Washington, Seattle 98195.

Abstract

Cells carefully regulate the generation and destruction of cAMP using diverse families of adenylate cyclases and phosphodiesterases. Genes for several cyclases have now been cloned, giving structural information about the enzymes and providing access to the remaining members of this family. A much larger family of phosphodiesterases has been uncovered and the regulatory properties of both the cyclases and phosphodiesterases provide diverse mechanisms to modulate intracellular cAMP. Most of the actions of cAMP are mediated through phosphorylation of substrates of the cAMP-dependent protein kinases. Recent progress has helped define the pathway between cAMP and the activation of gene transcription.

PMID:: 1652989; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Supplemental Content

Save items

Related citations in PubMed

Review New messages from old messengers: cAMP and mycobacteria. [Trends Microbiol. 2006]
Review New messages from old messengers: cAMP and mycobacteria.
Shenoy AR, Visweswariah SS. Trends Microbiol. 2006 Dec; 14(12):543-50. Epub 2006 Oct 19.
Review cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection. [J Muscle Res Cell Motil. 2002]
Review cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.
Saran S, Meima ME, Alvarez-Curto E, Weening KE, Rozen DE, Schaap P. J Muscle Res Cell Motil. 2002; 23(7-8):793-802.
Review Molecular diversity of cyclic AMP signalling. [Front Neuroendocrinol. 2000]
Review Molecular diversity of cyclic AMP signalling.
Antoni FA. Front Neuroendocrinol. 2000 Apr; 21(2):103-32.
Review Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. [Mol Microbiol. 1999]
Review Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae.
Thevelein JM, de Winde JH. Mol Microbiol. 1999 Sep; 33(5):904-18.
Review Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP. [Adv Enzyme Regul. 1995]
Review Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP.
Houslay MD. Adv Enzyme Regul. 1995; 35:303-38.

See reviews... See all...

Cited by 21 PubMed Central articles

Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis. [Front Neurosci. 2012]
Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis.
Kumar S, Ren Q, Beckley JH, O'Buckley TK, Gigante ED, Santerre JL, Werner DF, Morrow AL. Front Neurosci. 2012; 6:44. Epub 2012 Apr 9.
Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization. [PLoS One. 2011]
Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization.
Matthiesen K, Nielsen J. PLoS One. 2011; 6(9):e24392. Epub 2011 Sep 8.
Cell-type specific expression of a dominant negative PKA mutation in mice. [PLoS One. 2011]
Cell-type specific expression of a dominant negative PKA mutation in mice.
Willis BS, Niswender CM, Su T, Amieux PS, McKnight GS. PLoS One. 2011 Apr 12; 6(4):e18772. Epub 2011 Apr 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cyclic AMP second messenger systems.
Cyclic AMP second messenger systems.
Curr Opin Cell Biol. 1991 Apr ;3(2):213-7.

PubMed
Resting energy expenditure in severely burned children: analysis of agreement be...
Resting energy expenditure in severely burned children: analysis of agreement between indirect calorimetry and prediction equations using the Bland-Altman method.
Burns. 2006 May ;32(3):335-42. Epub 2006 Mar 10 .

PubMed
Identification of ligands for DAF-12 that govern dauer formation and reproductio...
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Cell. 2006 Mar 24 ;124(6):1209-23. Epub 2006 Mar 9 .

PubMed
Gene expression analysis of distinct populations of cells isolated from mouse an...
Gene expression analysis of distinct populations of cells isolated from mouse and human inner ear FFPE tissue using laser capture microdissection--a technical report based on preliminary findings.
Brain Res. 2006 May 26 ;1091(1):289-99. Epub 2006 Mar 10 .

PubMed
Bortezomib: an effective agent in extramedullary disease in multiple myeloma.
Bortezomib: an effective agent in extramedullary disease in multiple myeloma.
Eur J Haematol. 2006 May ;76(5):405-8. Epub 2006 Mar 9 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: