Measles remains a substantial cause of global childhood mortality, particularly in developing countries. In their joint strategic plan for Measles Mortality Reduction, 2001-2005, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) targeted 45 priority countries with the highest measles mortality for implementation of a comprehensive strategy for accelerated and sustained measles mortality reduction. Components of this strategy include achieving high routine vaccination coverage (>90%) in every district and ensuring that all children receive a second opportunity for measles vaccination. In May 2003, the World Health Assembly endorsed a resolution urging member countries to achieve a goal (adopted in 2002 by the United Nations General Assembly Special Session on Children) to reduce 1999 deaths resulting from measles by half by the end of 2005. This report updates progress toward this goal and introduces a new goal for measles mortality reduction by 2010.