Department of Internal Medicine, University Hospital Hôtel-Dieu, Place Alexis Ricordeau, 44 035, Nantes, France. mohamed.hamidou@chu-nantes.fr
The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.