Howard Hughes Medical Institute UCLA-DOE Institute for Genomics and Proteomics Box 951570 UCLA, Los Angeles, CA 90095-1570, USA. david@mbi.ucla.edu
The science of bioinformatics has developed in the wake of methods to determine the sequences of the informational macromolecules--DNAs, RNAs and proteins. But in a wider sense, the biological world depends in its every process on the transmission of information, and hence bioinformatics is the fundamental core of biology. We here give a consideration of some of the key problems of bioinformatics in the coming decade, and perhaps longer.