Breast Cancer Res. 2006;8(1):402. Epub 2006 Feb 22.

The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction.

Abstract

Overcoming dendritic cell (DC) dysfunction is a prerequisite for successful active immunotherapy against breast cancer. CD40 ligand (CD40L), a key molecule in the interface between T-lymphocytes and DCs, seems to be instrumental in achieving that goal. Commenting on our data that CD40L protects circulating DCs from apoptosis induced by breast tumor products, Lenahan and Avigan highlighted the potential of CD40L for immunotherapy. We expand on that argument by pointing to additional findings that CD40L not only rescues genuine DCs but also functionally improves populations of immature antigen-presenting cells that fill the DC compartment in patients with breast cancer.

PMID:: 16524455; [PubMed - indexed for MEDLINE]
PMCID:: PMC1413976

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

CD40 Ligand

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Breast Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. [Breast Cancer Res. 2006]
Spontaneous apoptosis of blood dendritic cells in patients with breast cancer.
Pinzon-Charry A, Maxwell T, McGuckin MA, Schmidt C, Furnival C, López JA. Breast Cancer Res. 2006; 8(1):R5. Epub 2005 Dec 16.
CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo. [Hepatology. 2008]
CD40ligand-expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo.
Gonzalez-Carmona MA, Lukacs-Kornek V, Timmerman A, Shabani S, Kornek M, Vogt A, Yildiz Y, Sievers E, Schmidt-Wolf IG, Caselmann WH, et al. Hepatology. 2008 Jul; 48(1):157-68.
Blood dendritic cells generated with Flt3 ligand and CD40 ligand prime CD8+ T cells efficiently in cancer patients. [J Immunother. 2006]
Blood dendritic cells generated with Flt3 ligand and CD40 ligand prime CD8+ T cells efficiently in cancer patients.
Davis ID, Chen Q, Morris L, Quirk J, Stanley M, Tavarnesi ML, Parente P, Cavicchiolo T, Hopkins W, Jackson H, et al. J Immunother. 2006 Sep-Oct; 29(5):499-511.
Review Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy. [Exp Oncol. 2007]
Review Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy.
Bereznaya NM, Chekhun VF. Exp Oncol. 2007 Mar; 29(1):2-12.
Review Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors. [Cell Res. 2006]
Review Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors.
Xia D, Moyana T, Xiang J. Cell Res. 2006 Mar; 16(3):241-59.

See reviews... See all...

Cited by 3 PubMed Central articles

Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations. [J Transl Med. 2009]
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations.
Kaneno R, Shurin GV, Tourkova IL, Shurin MR. J Transl Med. 2009 Jul 10; 7:58. Epub 2009 Jul 10.
CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer. [Breast Cancer Res. 2007]
CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer.
Esteva FJ, Wang J, Lin F, Mejia JA, Yan K, Altundag K, Valero V, Buzdar AU, Hortobagyi GN, Symmans WF, et al. Breast Cancer Res. 2007; 9(6):R87.
Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. [Br J Cancer. 2007]
Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer.
Pinzon-Charry A, Ho CS, Maxwell T, McGuckin MA, Schmidt C, Furnival C, Pyke CM, López JA. Br J Cancer. 2007 Nov 5; 97(9):1251-9. Epub 2007 Oct 9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfuncti...
The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction.
Breast Cancer Res. 2006 ;8(1):402. Epub 2006 Feb 22 .

PubMed
The potential role of ketamine in hospice analgesia: a literature review.
The potential role of ketamine in hospice analgesia: a literature review.
Consult Pharm. 2006 Jan ;21(1):51-7.

PubMed
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated...
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.
Cell. 1991 Aug 23 ;66(4):743-58.

PubMed
[Cochrane EPOC group: closing the gap between quality assurance and organization...
[Cochrane EPOC group: closing the gap between quality assurance and organization of care research and front line professionals].
Ann Ig. 2005 Nov-Dec ;17(6):585-90.

PubMed
[Evaluation of knowledge and health attitude towards cigarette smoking, alcohol ...
[Evaluation of knowledge and health attitude towards cigarette smoking, alcohol and drugs use among students].
Przegl Lek. 2005 ;62(10):1119-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: