IDrugs. 2006 Feb;9(2):128-35.

Neramexane (merz pharmaceuticals/forest laboratories).

Source

Clinical Neuropharmacology, Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. rammes@mpipsykl.mpg.de

Abstract

Merz Pharmaceuticals GmbH and Forest Laboratories Inc are developing neramexane, an oral N-methyl-D-aspartate antagonist, as a potential neuroprotectant for various central nervous system disorders, including Alzheimer's disease, and for the potential treatment of drug and alcohol dependence, and pain.

PMID:: 16523403; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Neurologic Diseases - MedlinePlus Health Information

Molecular Biology Databases

CYCLOPENTANE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Neramexane. [Drugs R D. 2002]
Review Neramexane.
[No authors listed]Drugs R D. 2002; 3(1):19-20.
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia. [Eur J Pain. 2008]
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Klein T, Magerl W, Hanschmann A, Althaus M, Treede RD. Eur J Pain. 2008 Jan; 12(1):17-29. Epub 2007 Apr 20.
Review Memantine. Merz. [Curr Opin Investig Drugs. 2002]
Review Memantine. Merz.
Kilpatrick GJ, Tilbrook GS. Curr Opin Investig Drugs. 2002 May; 3(5):798-806.
Effect of neramexane on ethanol dependence and reinforcement. [Eur J Pharmacol. 2004]
Effect of neramexane on ethanol dependence and reinforcement.
Kotlinska J, Biala G, Rafalski P, Bochenski M, Danysz W. Eur J Pharmacol. 2004 Oct 25; 503(1-3):95-8.
Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors. [Eur J Pharmacol. 2007]
Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.
Plazas PV, Savino J, Kracun S, Gomez-Casati ME, Katz E, Parsons CG, Millar NS, Elgoyhen AB. Eur J Pharmacol. 2007 Jul 2; 566(1-3):11-9. Epub 2007 Mar 24.

See reviews... See all...

Cited by 3 PubMed Central articles

Investigational drugs for the treatment of AD: what can we learn from negative trials? [Alzheimers Res Ther. 2011]
Investigational drugs for the treatment of AD: what can we learn from negative trials?
Jacobson SA, Sabbagh MN. Alzheimers Res Ther. 2011 Apr 15; 3(2):14. Epub 2011 Apr 15.
Review The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target? [Biochem Pharmacol. 2009]
Review The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?
Elgoyhen AB, Katz E, Fuchs PA. Biochem Pharmacol. 2009 Oct 1; 78(7):712-9. Epub 2009 May 27.
Review NMDA receptors in clinical neurology: excitatory times ahead. [Lancet Neurol. 2008]
Review NMDA receptors in clinical neurology: excitatory times ahead.
Kalia LV, Kalia SK, Salter MW. Lancet Neurol. 2008 Aug; 7(8):742-55.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
MedGen
Related information in MedGen
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Neramexane (merz pharmaceuticals/forest laboratories).
Neramexane (merz pharmaceuticals/forest laboratories).
IDrugs. 2006 Feb ;9(2):128-35.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: