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Nano Lett. 2006 Mar;6(3):496-500.

Single molecule nanometronome.

Author information

  • 1Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, 61801, USA.

Abstract

We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.

PMID:
16522050
[PubMed - indexed for MEDLINE]
PMCID:
PMC2597577
Free PMC Article
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