My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    Appl Environ Microbiol. 2006 Mar;72(3):2005-13.

    A three-dimensional computer model of four hypothetical mechanisms protecting biofilms from antimicrobials.

    Chambless JD, Hunt SM, Stewart PS.

    Source

    Center for Biofilm Engineering and Department of Chemical and Biological Engineering, Montana State University-Bozeman, Bozeman, MT 59717-3980, USA.

    Abstract

    Four hypothetical mechanisms for protection of biofilms against antimicrobials were incorporated into a three-dimensional model of biofilm growth and development. The model integrated processes of substrate utilization, diffusion, growth, cell migration, death, and detachment in a cellular automaton framework. Compared to simulations of unprotected biofilms, each of the protective mechanisms provided some tolerance to antimicrobial action. When the mechanisms were compared to each other, the behaviors of the four protective mechanisms produced distinct shapes of killing curves, nonuniform spatial patterns of survival and cell type distribution, and anticipated susceptibility patterns for dispersed biofilm cells. The differences between the protective mechanisms predicted in these simulations could guide the design of experiments to discriminate antimicrobial tolerance mechanisms in biofilms. Each of the mechanisms could be a plausible avenue of biofilm protection.

    PMID:
    16517649
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1393201
    Free PMC Article

    Images from this publication.See all images (10) Free text

    FIG. 2.
    FIG. 4.
    FIG. 6.
    FIG. 8.
    FIG. 10.
    FIG. 1.
    FIG. 3.
    FIG. 5.
    FIG. 7.
    FIG. 9.

    Publication Types, MeSH Terms, Substances, Grant Support

    Publication Types

    MeSH Terms

    Substances

    Grant Support

    LinkOut - more resources

    Full Text Sources

    Other Literature Sources

      Supplemental Content

      Icon for HighWire Press Icon for PubMed Central

      Save items

      loading

      Related citations in PubMed

      See reviews... See all...

      Cited by 6 PubMed Central articles

      See all...

      Related information

      • Related Citations
        Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
      • References for this PMC Article
        Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
      • Free in PMC
        Free full text articles in PMC
      • Cited in PMC
        Full-text articles in the PubMed Central Database that cite the current articles.

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk