Microbes Infect. 2006 Apr;8(4):1098-107. Epub 2006 Jan 19.

The ASK1-MAP kinase pathways in immune and stress responses.

Hayakawa T, Matsuzawa A, Noguchi T, Takeda K, Ichijo H.

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Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

PMID:: 16517200; [PubMed - indexed for MEDLINE]

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Review Apoptosis signal-regulating kinase 1 in stress and immune response. [Annu Rev Pharmacol Toxicol. 2008]
Review Apoptosis signal-regulating kinase 1 in stress and immune response.
Takeda K, Noguchi T, Naguro I, Ichijo H. Annu Rev Pharmacol Toxicol. 2008; 48:199-225.
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Cited by 6 PubMed Central articles

Reciprocal inhibition between the transforming growth factor-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter protein for TAK1. [J Biol Chem. 2012]
Reciprocal inhibition between the transforming growth factor-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding protein 2 (TAB2), an adapter protein for TAK1.
Kim SY, Shim JH, Chun E, Lee KY. J Biol Chem. 2012 Jan 27; 287(5):3381-91. Epub 2011 Dec 13.
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. [J Biol Chem. 2010]
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, et al. J Biol Chem. 2010 Oct 29; 285(44):33979-91. Epub 2010 Aug 4.
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The ASK1-MAP kinase pathways in immune and stress responses.
The ASK1-MAP kinase pathways in immune and stress responses.
Microbes Infect. 2006 Apr ;8(4):1098-107. Epub 2006 Jan 19 .

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