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Microbes Infect. 2006 Apr;8(4):1098-107. Epub 2006 Jan 19.

The ASK1-MAP kinase pathways in immune and stress responses.

Author information

  • 1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

PMID:
16517200
[PubMed - indexed for MEDLINE]

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