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Maturitas. 2006 Aug 20;55(1):76-81. Epub 2006 Mar 2.

Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women.

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  • 1Division of Obstetrics and Gynecology, Department of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. martin.imhof@meduniwien.ac.at

Abstract

OBJECTIVE:

To evaluate the effects of a non-prescription red clover extract (MF11 RCE, Melbrosin International, Vienna, Austria) on selected sex hormones and endometrium in postmenopausal women.

PATIENTS AND METHODS:

One-hundred and nine postmenopausal women with an age > or =40 years were randomly assigned to one of two groups either two capsules of MF11RCE (80mg isoflavone) per day for a 90 day period, or placebo of equal design. After a 7 day washout period, medication was crossed-over for another 90 days.

RESULTS:

Combined evaluation demonstrated that supplementation with MF11RCE (verum), in contrast to placebo, significantly increased plasma testosterone levels and decreased endometrial thickness.

CONCLUSION:

MF11RCE exerts a moderate effect on testosterone levels in postmenopausal women, while estradiol levels remained unchanged. The observed reduction of endometrial thickness provides further support for a safe role for isoflavones in terms of endometrial hyperplasia.

PMID:
16513301
[PubMed - indexed for MEDLINE]
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