Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2006 Mar;116(3):615-22.

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Author information

  • 1Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.


Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Write to the Help Desk