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J Clin Invest. 2006 Mar;116(3):615-22.

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Author information

  • 1Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Abstract

Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

PMID:
16511594
[PubMed - indexed for MEDLINE]
PMCID:
PMC1386111
Free PMC Article

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