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Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells.

Moon HS, Yang JS.

Mol Cells. 2006 Feb 28;21(1):7-20. Review.


Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.

Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD.

J Clin Invest. 2003 May;111(10):1547-54.


The mitochondriotoxic domain of Vpr determines HIV-1 virulence.

Brenner C, Kroemer G.

J Clin Invest. 2003 May;111(10):1455-7. No abstract available.


Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines.

Muthumani K, Zhang D, Hwang DS, Kudchodkar S, Dayes NS, Desai BM, Malik AS, Yang JS, Chattergoon MA, Maguire HC Jr, Weiner DB.

Oncogene. 2002 Jul 11;21(30):4613-25.


HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.

Muthumani K, Hwang DS, Desai BM, Zhang D, Dayes N, Green DR, Weiner DB.

J Biol Chem. 2002 Oct 4;277(40):37820-31. Epub 2002 Jul 2.


Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2.

Jacotot E, Ferri KF, El Hamel C, Brenner C, Druillennec S, Hoebeke J, Rustin P, M├ętivier D, Lenoir C, Geuskens M, Vieira HL, Loeffler M, Belzacq AS, Briand JP, Zamzami N, Edelman L, Xie ZH, Reed JC, Roques BP, Kroemer G.

J Exp Med. 2001 Feb 19;193(4):509-19.

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