Clin Nephrol. 2006 Feb;65(2):134-7.

Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a college football player taking creatine supplements.

Source

Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Abstract

We describe a college football player and weight-lifter who unexpectedly developed rhabdomyolysis and nonoliguric acute renal failure (ARF) following arthroscopic knee surgery. There was swelling and pain without evidence of a compartment syndrome postoperatively. The patient reported that he was an avid weight-lifter and that he was taking up to 10 g/d of a creatine supplement during the 6 weeks prior to this surgery. His ARF resolved over several days, with a peak serum creatinine of 2.3 mg/dl and peak creatine kinase (CK) of 194,000 U/l, following administration of intravenous fluids, mannitol, and sodium bicarbonate. Given the rarity of clinically significant rhabdomyolysis with this type of operation, we suggest that the patient's use of creatine increased the risk of skeletal muscle injury due to ischemia from intra-operative tourniquet application.

Comment in

Clin Nephrol. 2007 Mar;67(3):198-9; author reply 199.

PMID:: 16509464; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Creatine

LinkOut - more resources

Full Text Sources

EBSCO

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

CREATINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

[Acute rhabdomyolysis: a case report and literature review]. [Acta Med Croatica. 2008]
[Acute rhabdomyolysis: a case report and literature review].
Mrsić V, Nesek Adam V, Grizelj Stojcić E, Rasić Z, Smiljanić A, Turcić I. Acta Med Croatica. 2008 Jul; 62(3):317-22.
[Acute renal failure due to rhabdomyolysis in McArdle's disease following binge drinking with seizures]. [Dtsch Med Wochenschr. 2001]
[Acute renal failure due to rhabdomyolysis in McArdle's disease following binge drinking with seizures].
Haslinger B, Küchle C, Sitter T, Held E. Dtsch Med Wochenschr. 2001 Nov 9; 126(45):1265-8.
Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds. [J Trauma. 2002]
Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds.
Sandhu RS, Como JJ, Scalea TS, Betts JM. J Trauma. 2002 Oct; 53(4):761-3; discussion 763-4.
Review Severe rhabdomyolysis with renal failure after intranasal cocaine use. [J Emerg Med. 1997]
Review Severe rhabdomyolysis with renal failure after intranasal cocaine use.
Horowitz BZ, Panacek EA, Jouriles NJ. J Emerg Med. 1997 Nov-Dec; 15(6):833-7.
Review Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review. [Sao Paulo Med J. 2005]
Review Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review.
Daher Ede F, Silva Júnior GB, Brunetta DM, Pontes LB, Bezerra GP. Sao Paulo Med J. 2005 Jan 2; 123(1):33-7. Epub 2005 Mar 31.

See reviews... See all...

Cited by 3 PubMed Central articles

The effects of a high dosage of creatine and caffeine supplementation on the lean body mass composition of rats submitted to vertical jumping training. [J Int Soc Sports Nutr. 2011]
The effects of a high dosage of creatine and caffeine supplementation on the lean body mass composition of rats submitted to vertical jumping training.
Franco FS, Costa NM, Ferreira SA, Carneiro-Junior MA, Natali AJ. J Int Soc Sports Nutr. 2011 Mar 1; 8:3. Epub 2011 Mar 1.
A case of rhabdomyolysis associated with use of a pneumatic tourniquet during arthroscopic knee surgery. [Korean J Intern Med. 2010]
A case of rhabdomyolysis associated with use of a pneumatic tourniquet during arthroscopic knee surgery.
Lee YG, Park W, Kim SH, Yun SP, Jeong H, Kim HJ, Yang DH. Korean J Intern Med. 2010 Mar; 25(1):105-9. Epub 2010 Feb 26.
Trauma, systemic inflammatory response syndrome, dietary supplements, illicit steroid use and a questionable malignant hyperthermia reaction. [Anesth Analg. 2009]
Trauma, systemic inflammatory response syndrome, dietary supplements, illicit steroid use and a questionable malignant hyperthermia reaction.
Capacchione JF, Radimer MC, Sagel JS, Kraus GP, Sambuughin N, Muldoon SM. Anesth Analg. 2009 Mar; 108(3):900-3.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a ...
Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a college football player taking creatine supplements.
Clin Nephrol. 2006 Feb ;65(2):134-7.

PubMed
In vivo distribution of opioid receptors in man in relation to the cortical proj...
In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography.
Neurosci Lett. 1991 May 13 ;126(1):25-8.

PubMed
Bridging the "know-do" gap in healthcare priority-setting: what role has academi...
Bridging the "know-do" gap in healthcare priority-setting: what role has academic research played?
Healthc Manage Forum. 2005 Winter ;18(4):26-32.

PubMed
[Therapy of mental states at high risk for psychosis: preliminary results from H...
[Therapy of mental states at high risk for psychosis: preliminary results from Hungary].
Orv Hetil. 2006 Feb 5 ;147(5):201-4.

PubMed
Identification of two fructose transport and phosphorylation pathways in Xanthom...
Identification of two fructose transport and phosphorylation pathways in Xanthomonas campestris pv. campestris.
Mol Gen Genet. 1991 Jul ;227(3):465-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: