Semin Respir Crit Care Med. 2006 Feb;27(1):29-33.

Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia and severe sepsis.

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Service de Réanimation Médicale, Hôpital Central, Nancy Cedex, France. s.gibot@chu-nancy.fr

Abstract

The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule involved in the inflammatory response. It belongs to the immunoglobulin superfamily and is expressed on the surface of neutrophils, mature monocytes, and macrophages. The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components. The expression of the membrane-bound TREM-1 is strongly upregulated on monocytes during sepsis. Besides its membranous form, a soluble counterpart of TREM-1 exists that is specifically released during several infectious processes. The measurement of that soluble form in biological fluids may be useful as a diagnostic tool, especially during severe sepsis and pneumonia. Moreover, the evolutionary pattern of TREM-1 may be interesting during the follow-up of septic patients.

PMID:: 16508879; [PubMed - indexed for MEDLINE]

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Cited by 5 PubMed Central articles

Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. [BMC Infect Dis. 2011]
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Rivera-Chavez FA, Minei JP. Surg Infect (Larchmt). 2009 Oct; 10(5):435-9.
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Radsak MP, Taube C, Haselmayer P, Tenzer S, Salih HR, Wiewrodt R, Buhl R, Schild H. Clin Dev Immunol. 2007; 2007:52040.

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