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J Hypertens. 2006 Feb;24(2):287-92.

In a population-based prospective study, no association between high blood pressure and mortality after age 85 years.

Author information

  • 1Department of Gerontology and Geriatrics, C2-R, Leiden University Medical Centre, Leiden, The Netherlands. t.van_bemmel@lumc.nl

Abstract

OBJECTIVE:

To study the impact of a history of hypertension and current blood pressure on mortality in the oldest old.

DESIGN:

An observational population-based cohort study.

SETTING:

Community city of Leiden, The Netherlands.

PARTICIPANTS:

Five hundred and ninety-nine inhabitants of the birth-cohort 1912-1914 were enrolled on their 85th birthday. There were no selection criteria related to health or demographic characteristics.

INTERVENTIONS:

The mean follow-up was 4.2 years. Medical histories were obtained from general practitioners. Medication histories were obtained from the participant's pharmacist. Blood pressure was measured twice at baseline.

MAIN OUTCOME MEASURES:

All cause and cardiovascular mortality.

RESULTS:

Five hundred and seventy-one participants were included, 39.2% had a history of hypertension. During follow-up 290 participants died, 119 due to cardiovascular causes. Compared to participants without a history of hypertension, those with a history of hypertension had increased mortality from cardiovascular causes [relative risk (RR) 1.60, confidence interval (CI) 1.06-2.40] but equal mortality from all causes (RR 1.19, CI 0.91-1.55). High blood pressure at baseline (age 85) was not a risk factor for mortality. Baseline blood pressure values below 140/70 mmHg (n = 48) were associated with excess mortality, predominantly in participants with a history of hypertension.

CONCLUSION:

In the oldest old, high blood pressure is not a risk factor for mortality, irrespective of a history of hypertension. Blood pressure values below 140/70 mmHg are associated with excess mortality.

Comment in

PMID:
16508574
[PubMed - indexed for MEDLINE]
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