Comparison of gold and silver standard family classifications to Pfam for the gold standard enolase superfamily. The outer ring represents Pfam family classifications. Sequences that match multiple Pfam HMMs, all of which correspond to a single SFLD functional domain (for example, 'Enolase_N', representing the amino terminus of the enzyme enolase and 'Enolase', representing the carboxyl terminus of the enzyme enolase), are shown with a single designation in the figure to simplify the illustration. (a) The inner ring represents gold standard family classifications. Gray regions represent enzymes that can be assigned to the gold standard enolase superfamily, but cannot be confidently assigned to a gold standard family. (b) The inner ring represents silver standard family classifications. Gray regions represent enzymes that can be assigned to the gold standard enolase superfamily, but cannot be confidently assigned to a silver standard family.