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    CMAJ. 2006 Feb 28;174(5):649-59.

    Hepatitis C: a review for primary care physicians.

    Wong T, Lee SS.

    Source

    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada and the University of Ottawa, Ottawa, Ont. tom_wong@hc-sc.gc.ca

    Erratum in

    • CMAJ. 2006 May 9;174(10):1450.

    Abstract

    Primary care physicians see many of the estimated 250 000 Canadians chronically infected with the hepatitis C virus (HCV). Of this number, about one-third are unaware they are infected, which constitutes a large hidden epidemic. They continue to spread HCV unknowingly and cannot benefit from advances in antiviral therapy that may clear them of the virus. Many HCV-infected people remain asymptomatic, which means it is important to assess for risk factors and test patients accordingly. The third-generation enzyme immunoassay for HCV antibodies is a sensitive and specific test, although the presence of the virus can be confirmed by polymerase chain reaction testing for HCV RNA in some circumstances. Pegylated interferon-alpha and ribavirin combination therapy clears the virus in about 45%-80% of patients, depending on viral genotype. Preventive strategies and counselling recommendations are also reviewed.

    Comment in

    PMID:
    16505462
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1389829
    Free PMC Article

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