Making the grade with models of persistent activity

Joshua T Dudman; Steven A Siegelbaum

doi:10.1016/j.neuron.2006.02.010

Making the grade with models of persistent activity

Neuron. 2006 Mar 2;49(5):649-51. doi: 10.1016/j.neuron.2006.02.010.

Authors

Joshua T Dudman¹, Steven A Siegelbaum

Affiliation

¹ Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.

PMID: 16504940
DOI: 10.1016/j.neuron.2006.02.010

Abstract

Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computational approaches.

Publication types

Comment

MeSH terms

Action Potentials / physiology*
Animals
Calcium / metabolism
Electric Stimulation / methods
Models, Neurological*
Neurons / physiology*

Substances

Calcium