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Cancer Lett. 2007 Jan 8;245(1-2):331-6. Epub 2006 Feb 28.

Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11.

Author information

  • 1Medical Faculty, Institute of Immunology, Technical University of Dresden, Fetscherstr. 74, 01307 Dresden, Germany. mschmitz@rcs.urz.tu-dresden.de

Abstract

The development of T cell-based immunotherapies of cancer depends on the identification of tumor-associated antigens capable of eliciting tumor-directed cytotoxic T cell responses. In malignant glioma the number of well-defined target antigens for cytotoxic T lymphocytes (CTLs) is still very limited. Recently, we demonstrated the abundant and specific overexpression of the transcription factor SOX11 in malignant glioma. Here, we describe the SOX11-derived peptide LLRRYNVAKV which is capable of inducing human leukocyte antigen-A*0201-restricted and tumor-reactive CTLs. This novel CTL epitope may serve as an attractive candidate for a T cell-based immunotherapy of glioma.

PMID:
16504379
[PubMed - indexed for MEDLINE]
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