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Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. Epub 2006 Feb 28.

Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

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  • 1Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. adrian.2.hall@gsk.com

Abstract

We describe the generation of novel EP(1) receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.

PMID:
16503138
[PubMed - indexed for MEDLINE]
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