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Ann Neurol. 2006 Mar;59(3):499-503.

Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis.

Author information

  • 1Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. ethacker@hsph.harvard.edu

Abstract

OBJECTIVE:

To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS).

METHODS:

We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS.

RESULTS:

The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.

INTERPRETATION:

We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.

PMID:
16502434
[PubMed - indexed for MEDLINE]
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