Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bull World Health Organ. 2006 Feb;84(2):120-6. Epub 2006 Feb 23.

Effects of insecticide-treated bednets during early infancy in an African area of intense malaria transmission: a randomized controlled trial.

Author information

  • 1Department of Tropical Hygiene and Public Health, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. olaf.mueller@urz.uni-heidelberg.de

Abstract

OBJECTIVE:

Insecticide-impregnated bednets and curtains have been shown by many studies to be effective against malaria. However, because of possible interactions with immunity development, treated bednets may cause no effect at all or even an increase in malaria morbidity and mortality in areas of high transmission. To clarify this issue, we did a randomized controlled trial to assess the long-term effects of bednet protection during early infancy.

METHODS:

A total of 3387 neonates from 41 villages in rural Burkina Faso were individually randomized to receive either bednet protection from birth (group A) or from age 6 months (group B). Primary outcomes were all-cause mortality in all study children and incidence of falciparum malaria in a representative subsample of the study population.

FINDINGS:

After a mean follow-up of 27 months, there were 129 deaths in group A and 128 deaths in group B rate ratio (RR) 1.0 (95% confidence interval (CI): 0.78-1.27)). Falciparum malaria incidence was lower in group A than in group B, during early (0-5 months) and late infancy (6-12 months) (RR 3.1, 95% CI: 2.0-4.9; RR 1.3, 95% CI: 1.1-1.6) and rates of moderate to severe anaemia were significantly lower during late infancy (11.5% vs 23.3%, P = 0.008), but there were no differences between groups in these parameters in children older than 12 months.

CONCLUSION:

The findings from this study provide additional evidence for the efficacy of insecticide-treated nets in young children living in areas of intense malaria transmission.

PMID:
16501729
[PubMed - indexed for MEDLINE]
PMCID:
PMC2626534
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Scientific Electronic Library Online Icon for PubMed Central
    Loading ...
    Write to the Help Desk