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Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S18-22.

Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium.

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  • 1Division of Cardiothoracic Surgery, Columbia University, New York, NY, USA. tpm2102@columbia.edu


Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.

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