Cell. 2006 Feb 24;124(4):815-22.

The evolution of adaptive immune systems.

Source

Division of Developmental and Clinical Immunology, Departments of Medicine, Microbiology, Pediatrics, and Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. max.cooper@ccc.uab.edu

Abstract

A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led to the evolution of alternative ways for lymphocytes to generate diverse antigen receptors for use in recognizing and repelling pathogen invaders. All jawed vertebrates assemble their antigen-receptor genes through recombinatorial rearrangement of different immunoglobulin or T cell receptor gene segments. The surviving jawless vertebrates, lampreys and hagfish, instead solved the receptor diversification problem by the recombinatorial assembly of leucine-rich-repeat genetic modules to encode variable lymphocyte receptors. The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components.

PMID:: 16497590; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Immunoglobulins

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Immune System and Disorders - MedlinePlus Health Information

Supplemental Content

Related citations

Review The evolution of adaptive immunity. [Annu Rev Immunol. 2006]
Review The evolution of adaptive immunity.
Pancer Z, Cooper MD. Annu Rev Immunol. 2006; 24:497-518.
Review Mechanisms of antigen receptor evolution. [Semin Immunol. 2004]
Review Mechanisms of antigen receptor evolution.
Eason DD, Cannon JP, Haire RN, Rast JP, Ostrov DA, Litman GW. Semin Immunol. 2004 Aug; 16(4):215-26.
Review The evolution of adaptive immunity in vertebrates. [Adv Immunol. 2011]
Review The evolution of adaptive immunity in vertebrates.
Hirano M, Das S, Guo P, Cooper MD. Adv Immunol. 2011; 109:125-57.
Review New insights into alternative mechanisms of immune receptor diversification. [Adv Immunol. 2005]
Review New insights into alternative mechanisms of immune receptor diversification.
Litman GW, Cannon JP, Rast JP. Adv Immunol. 2005; 87:209-36.
Review Reconstructing immune phylogeny: new perspectives. [Nat Rev Immunol. 2005]
Review Reconstructing immune phylogeny: new perspectives.
Litman GW, Cannon JP, Dishaw LJ. Nat Rev Immunol. 2005 Nov; 5(11):866-79.

See reviews... See all...

Cited by 35 PubMed Central articles

Viral ancestors of antiviral systems. [Viruses. 2011]
Viral ancestors of antiviral systems.
Villarreal LP. Viruses. 2011 Oct; 3(10):1933-58. Epub 2011 Oct 20.
Comparative genomics approach to detecting split-coding regions in a low-coverage genome: lessons from the chimaera Callorhinchus milii (Holocephali, Chondrichthyes). [Brief Bioinform. 2011]
Comparative genomics approach to detecting split-coding regions in a low-coverage genome: lessons from the chimaera Callorhinchus milii (Holocephali, Chondrichthyes).
Dessimoz C, Zoller S, Manousaki T, Qiu H, Meyer A, Kuraku S. Brief Bioinform. 2011 Sep; 12(5):474-84. Epub 2011 Jun 28.
Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomes. [Integr Comp Biol. 2010]
Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomes.
Smith JJ, Saha NR, Amemiya CT. Integr Comp Biol. 2010 Jul; 50(1):130-7. Epub 2010 Apr 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The evolution of adaptive immune systems.
The evolution of adaptive immune systems.
Cell. 2006 Feb 24 ;124(4):815-22.

PubMed
Dimensional representations of DSM-IV cluster A personality disorders in a popul...
Dimensional representations of DSM-IV cluster A personality disorders in a population-based sample of Norwegian twins: a multivariate study.
Psychol Med. 2006 Nov ;36(11):1583-91. Epub 2006 Aug 8 .

PubMed
L-arginine supplementation improves exercise capacity after a heart transplant.
L-arginine supplementation improves exercise capacity after a heart transplant.
Am J Clin Nutr. 2010 May ;91(5):1261-7. Epub 2010 Mar 3 .

PubMed
Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: di...
Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.
Neuro Endocrinol Lett. 2009 ;30(6):677-93.

PubMed
Structure prediction for CASP7 targets using extensive all-atom refinement with ...
Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home.
Proteins. 2007 ;69 Suppl 8:118-28.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: