Bacterial adhesion and entry into host cells. [Cell. 2006]

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1: Cell. 2006 Feb 24;124(4):715-27. Links

Bacterial adhesion and entry into host cells.

Pizarro-Cerdá J, Cossart P.

Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, F-75015 France. pizarroj@pasteur.fr

Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.

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