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Cell. 2006 Feb 24;124(4):703-14.

Bacterial genomics and pathogen evolution.

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  • 1Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.


The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date.

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