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Cancer. 1991 Aug 15;68(4):889-92.

Familial juvenile polyposis coli and colorectal cancer.

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  • 1Department of Surgery, University College, Dublin, Ireland.


A 40-year-old mother and her 7-year-old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5-cm severely dysplastic villous adenoma without invasive carcinoma. Foci of adenomatous change in juvenile polyps were present in the son's specimen. The histologic features of both cases suggest a sequence of change from juvenile polyps to adenomatous polyps to cancer.

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