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Br J Cancer. 2006 Mar 13;94(5):620-4.

Tumours and tremors: how PTEN regulation underlies both.

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  • 1Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.


Mutations of the tumour suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are seen in many human cancers. However, dysregulation of PTEN may be involved in other disease states such as Parkinson's disease. This minireview describes recent work examining PTEN regulation and its implications for the development of both cancer and neurodegenerative disease.

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